Results
| PMID | 11718025 |
| Gene Name | HLA-DQA1 |
| Condition | Endometriosis |
| Association |
Associated |
| Mutation | HLA-DQA1 * 0401, HLA-DQA1 * 0301 |
| Population size | 95 |
| Population details | 95 (51 patients with endometriosis, 44 control women who had laparoscopic sterilization and without endometriosis) |
| Sex | Female |
| Associated genes | HLA-DQA1 |
| Other associated phenotypes |
Endometriosis |
|
Zhonghua Fu Chan Ke Za Zhi. 2001 Jul;36(7):405-7. Zong, L| He, Y| Pan, D Department of Obstetrics and Gynecology, Zhujiang Hospital of the First Military Medical University, Guangzhou 510282, China. OBJECTIVE: To study the genetic susceptibility in patients with endometriosis by genotyping their human leukocyte antigen-DQA1 (HLA-DQA1) alleles. METHODS: The allelic types of HLA-DQA1 were detected by polymerase chain reaction single specific primers (PCR-SSP) technique in 51 patients with endometriosis proven by laparoscopy or histological examination, and 44 control women who had laparoscopic sterilization and without endometriosis. RESULTS: The frequency of HLA-DQA * 0401 allele (12%) in patients with endometriosis group was markedly higher than that in the control group (0%) (P = 0.019). Contrarily, the frequency of HLA-DQA1 * 0301 allele (39%) in control group was higher than that in endometriosis group (14%) (P = 0.005, odds ratio = 0.253). CONCLUSION: Our result indicated that HLA-DQA1 * 0401 may be a susceptible gene in correlation with endometriosis, whereas HLA-DQA1 * 0301 may be a protective gene against endometriosis. Mesh Terms: Adult| Alleles| China/epidemiology| Endometriosis/epidemiology/*genetics| Female| Gene Frequency| Genetic Predisposition to Disease| HLA-DQ Antigens/*genetics| HLA-DQ alpha-Chains| Humans| Middle Aged|DA 2002/01/05 10:01 |
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